drug combinations

A Note from TripSit

WARNING! For educational purposes: We do not endorse any of these combinations. This [chart] will always be ‘work in progress’. It is extremely important to be safe at all times! See below the graphic for important information regarding specific combinations.

This chart is meant as a quick reference guide and additional research MUST always be done. If you use this chart or information on your site you must link to the full summaries and display this message.

If you want to give [TripSit] some feedback/recommendation/comment on the chart, you can contact [them]:
Join #content channel on IRC
Email: [email protected]


Although most psychoactive substances are quite powerful in their own rights, some psychonauts may choose to combine two or more of them at the same time to take their experience even further. Combining multiple psychoactive substances during one session has the potential to jettison the user into brand-new psychedelic territories, or catalyze new perspectives on life or the concept of reality. However, it can also result in severe physical discomfort, relentless psychological trauma, and even death. Because of the high risk potential, this advanced technique should not be attempted by those new to psychedelics, and even those with years of experience should still tread lightly and proceed with extreme caution.

In an effort to reduce the potential dangers of drug combining, the harm reduction website TripSit created Version 3.0 of the Guide to Drug Combinations chart in 2016 (shown above.) Although the image featured above is quite small, TripSit also offers a larger version of the chart for improved legibility. We advise taking a close look at the larger version if you want to learn more about the potential effects and risks that come with combining psychoactive substances. We have put together the following chart reading guide as an introduction to this resource, which we hope will help our readers make informed decisions and reduce any potential harms resulting from combining drugs.


How to Read the Chart

The Guide to Drug Combinations chart is fairly easy to read. First, simply identify the first substance you would like to reference on the chart’s X axis. Next, locate the second substance on the Y axis. The area in the center of the chart where the first substance’s column meets the second substance’s row will display the anticipated level of risk for that particular combination. More information about the various risk categories can be found below.

In addition to providing translated versions of this chart in Spanish, German, French, and Esperanto, TripSit also has detailed descriptions of specific combinations on its Drug Combinations webpage, located a few sections below the chart. These descriptions offer more information about each unique combination of substances, which can be extremely helpful—potentially even life-saving—if you are considering using two or more drugs at the same time.



TripSit created a total of six categories that are used in the Guide to Drug Combinations chart. Each category assesses the safety level of a drug combination, as well as whether the combination will cause a synergistic effect. A combination that is potentially “synergistic” may result in an effect greater than the sum of its parts.


Low Risk and Synergy: This category describes substances that are unlikely to cause adverse or undesirable reactions aside from those that are ordinarily anticipated from using each substance individually. In addition, the substances are likely to have a synergistic effect when combined.

Low Risk and No Synergy: This combination is not likely to cause an adverse or undesirable reaction when used carefully. In addition, there is no synergistic effect—the effects are simply additive.

Low Risk and Decrease: A drug combination that falls into this category will have a low risk of causing an adverse or undesirable reaction, and each substance’s effects will be dampened, rather than amplified.

Caution: While not likely to be physically harmful, a drug combination in this category may produce undesirable effects like physical discomfort or overstimulation. Frequent or high-dosage use may result in physical health issues, and the potential for synergistic effect is possible—albeit unpredictable. As the category name suggests, users who wish to experiment with a drug combination in this category should proceed with caution.

Unsafe: When a drug combination is categorized as unsafe, there is a severe risk of physical harm to the user. These combinations should be approached with extreme caution, and it is best to avoid them entirely.

Dangerous: The final category includes drug combinations that are known to be extremely harmful both physically and psychologically. In fact, the reactions from experimenting with these combinations are wildly unpredictable and there is a realistic chance of death. These combinations should be avoided at all costs.



The concept of combining multiple psychoactive substances is appealing to some psychonauts, and this practice can provide both positive and negative outcomes. To prevent both psychological and physical issues from occurring, it is always best to learn as much about the potential effects a drug combination may produce before trying it. Psychedelic Times would like to thank TripSit for the hard work that went into putting together the Guide to Drug Combinations, and we hope that it will be used wisely by those choosing to experiment with various drug combinations.


Disclaimer: Psychedelic Times presents this information with the sole intention of providing harm reduction information, and does not advocate or promote the use of illegal psychoactive substances. We advise our readers to use extreme caution when deciding whether or not to combine multiple substances.